کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6021226 | 1580440 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin](/preview/png/6021226.png)
چکیده انگلیسی
We investigated the overlap shared between the immunoglobulin (Ig) proteome of the cerebrospinal fluid (CSF) and the B cell Ig-transcriptome of CSF and the central nervous system (CNS) tissue of three patients with multiple sclerosis. We determined the IgG-proteomes of CSF by mass spectrometry, and compared them to the IgG-transcriptomes from CSF and brain lesions, which were analyzed by cDNA cloning. Characteristic peptides that were identified in the CSF-proteome could also be detected in the transcriptomes of both, brain lesions and CSF, providing evidence for a strong overlap of the IgG repertoires in brain lesions and in the CSF.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 233, Issues 1â2, April 2011, Pages 245-248
Journal: Journal of Neuroimmunology - Volume 233, Issues 1â2, April 2011, Pages 245-248
نویسندگان
Birgit Obermeier, Laura Lovato, Reinhard Mentele, Wolfgang Brück, Ignasi Forne, Axel Imhof, Friedrich Lottspeich, Katherine W. Turk, Simon N. Willis, Hartmut Wekerle, Reinhard Hohlfeld, David A. Hafler, Kevin C. O'Connor, Klaus Dornmair,