کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
602336 | 879972 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Studying the interactions of drugs and hydrophobic model membranes using contact angle goniometry
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
This study demonstrates a method where contact angle goniometry combined with surface tension measurements is used to assess the interactions of drugs with the hydrophobic core of a biological membrane. To this end, self-assembled monolayers (SAMs) of two alkanethiol and one thiolipid on Au(1 1 1) surfaces are used as model membranes and their interaction with six β-blockers is studied. The Gibbs equation and the Langmuir adsorption isotherm are used to determine the partition coefficients for the adsorption of the drugs, which are compared to the octanol–water partition coefficients as well as the liposome–water partition coefficients. The ability of the different SAMs to serve as model membranes in partitioning of drugs is discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 71, Issue 1, 1 June 2009, Pages 107–112
Journal: Colloids and Surfaces B: Biointerfaces - Volume 71, Issue 1, 1 June 2009, Pages 107–112
نویسندگان
Marjukka Ikonen, Lasse Murtomäki, Kyösti Kontturi,