کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6023365 | 1580874 | 2016 | 44 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Awake reactivation of emotional memory traces through hippocampal-neocortical interactions
ترجمه فارسی عنوان
بیدار شدن مجدد حافظه های هیجانی از طریق تعامل هیوکوکلامی و نئوکورتیک
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کلمات کلیدی
تهدید ترس، انگیختگی، تجزیه و تحلیل شباهت نمایشی، آمیگدالا، هیپوکامپ، اتصال حالت عملکرد حالت حالت استراحت،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
چکیده انگلیسی
Emotionally arousing experiences are typically well remembered not only due to immediate effects at encoding, but also through further strengthening of subsequent consolidation processes. A large body of research shows how neuromodulatory systems promote synaptic consolidation. However, how emotionally arousing experiences alter systems-level interactions, presumably a consequence of modifications at a synaptic level, remains unclear. Animal models predict that memory traces are maintained by spontaneous reactivations across hippocampal-neocortical circuits during “offline” periods such as post-learning rest, and suggest this might be stronger for emotional memories. The present study was designed to test this hypothesis in humans using functional Magnetic Resonance Imaging. Participants underwent a two-category localizer paradigm followed by a categorical differential delay fear conditioning paradigm interleaved with blocks of awake rest. Counterbalanced across participants, exemplars of one category (CSÂ +), but not the other (CSÂ â), were paired with mild electrical shocks. Fear recall (differential conditioned pupil dilation) was tested 24Â h later. Analyses of the localizer paradigm replicate earlier work showing category-specific response patterns in neocortical higher-order visual regions. Critically, we show that during post-learning rest, spontaneous reactivation of these neocortical patterns was stronger for the CSÂ + than the CSÂ â category. Furthermore, hippocampal connectivity with the regions exhibiting these reactivations predicted strength of fear recall 24Â h later. We conclude that emotional arousal during learning promotes spontaneous post-learning reactivation of neocortical representations of recent experiences, which leads to better memory when coinciding with hippocampal connectivity. Our findings reveal a systems-level mechanism that may explain the persistence of long-term memory for emotional experiences.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 134, 1 July 2016, Pages 563-572
Journal: NeuroImage - Volume 134, 1 July 2016, Pages 563-572
نویسندگان
Lycia D. de Voogd, Guillén Fernández, Erno J. Hermans,