کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
602449 879977 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Influence of additives on the clouding phenomenon of chlorpromazine hydrochloride solutions
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Influence of additives on the clouding phenomenon of chlorpromazine hydrochloride solutions
چکیده انگلیسی
Herein we report the effect of various additives (viz. alcohols, cycloalcohols, amino acids, sugars, ureas) on the clouding phenomenon observed in 50 mM chlorpromazine hydrochloride (CPZ) drug solutions (prepared in 10 mM sodium phosphate buffer). Long chain alcohols (except octanol), cyclohexanol and allylalcohol increased the cloud point (CP) followed by a decrease with the increase in alcohol concentration but short chain alcohols affected the CP insignificantly. Effect of amino acids depended upon their nature: acidic and salts of basic amino acids increased the CP while basic amino acids depressed it; non-polar and uncharged polar amino acids caused small changes in CP. Additives of urea family decreased the CP. All sugars caused a decrease in CP, which is in consonance to their effect on the critical micellar concentration. The overall behavior is explained on the basis of additives affecting the solvent as well as micelle aggregation and/or structure.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 63, Issue 1, 1 May 2008, Pages 122-128
نویسندگان
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