کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
602560 879983 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Characterization of the human PAP1 gene and its homologue possible involvement in mouse embryonic development
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Characterization of the human PAP1 gene and its homologue possible involvement in mouse embryonic development
چکیده انگلیسی

We have identified PAP1 gene, a novel member of the immunoglobulin superfamily (IGSF) from U251-pTet-p53 cell line, which carried a wild-type p53 transgene. The gene has been localised to chromosome 16p12-13. Alignment of the predicted protein sequence for Human, Pan troglodytes, Canis, Mus musculus and Gallus gallus revealed it was highly conserved. Its homologue, IGSF6, possible involves in mouse embryonic development. The presence of IGSF6 specific transcript was detected by Northern blot in the RNAs extracted from 11 to 14 day postconception. IGSF6 expression is different in mouse embryos of the different ages. In situ hybridization performed on mice embryos sections showed the differential presence of IGSF6 in developing lung and kidney. This structure and differential expression suggests a function involvement in embryonic development, perhaps involvement in cell proliferation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces B: Biointerfaces - Volume 52, Issue 1, 1 September 2006, Pages 22–30
نویسندگان
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