کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6026783 1580906 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The integrity of the cholinergic system determines memory performance in healthy elderly
ترجمه فارسی عنوان
یکپارچگی سیستم کولینرژیک عملکرد حافظه در سالمندان سالم را تعیین می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
چکیده انگلیسی


- Acetylcholinesterase activity predicts episodic memory performance in healthy humans.
- This effect is observed within structures known to be memory relevant.
- The relationship is independent of gray matter atrophy.

The cholinergic system plays a central role in episodic memory-related processes in health and disease. Cerebral acetylcholinesterase (AChE) activity, a measure of the integrity of the cholinergic system, can be assessed in vivo using positron emission tomography (PET) and [11C]N-methyl-4-piperidyl acetate (MP4A). A close relationship between the kinetic constant k3 of MP4A and mnestic functions has been demonstrated for patients suffering from amnestic mild cognitive impairment and Alzheimer's disease. Under the hypothesis that AChE activity and memory are intimately linked in older age, we obtained MP4A-PET and structural magnetic resonance images as well as neuropsychological data from fourteen healthy older adults. Multiple regression analysis revealed that AChE activity in areas previously implicated in mnestic functions predicted episodic memory performance irrespective of cortical atrophy. Data suggest that in older adults the integrity of the cholinergic system underlies inter-individual variability in memory function.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 100, 15 October 2014, Pages 481-488
نویسندگان
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