کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6027080 | 1580907 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
tDCS-induced alterations in GABA concentration within primary motor cortex predict motor learning and motor memory: A 7Â T magnetic resonance spectroscopy study
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کلمات کلیدی
TMSNaANAAGMRSN-acetylaspartateBOLDtDCSN-acetylaspartylglutamate - N-acetylaspartilglutamateγ-amino-butyric acid - γ-آمینو اسید بوتیریکMRI - امآرآی یا تصویرسازی تشدید مغناطیسیTranscranial direct current stimulation - تحرک جریان مستقیم TranscranialTranscranial magnetic stimulation - تحریک مغناطیسی مغزMagnetic resonance imaging - تصویربرداری رزونانس مغناطیسیfunctional magnetic resonance imaging - تصویرسازی تشدید مغناطیسی کارکردیfMRI - تصویرسازی تشدید مغناطیسی کارکردیblood-oxygen-level-dependent - خون وابسته به اکسیژنPsychological - روانشناسیmagnetic resonance spectroscopy - طیف سنجی رزونانس مغناطیسیBiological sciences - علوم بیولوژیکیCognitive sciences - علوم شناختیprimary visual cortex - قشر بصری اولیهprimary motor cortex - قشر حرکتی اولیهNeuroscience - نوروساینسGABA - گاباMotor learning - یادگیری حرکتی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that alters cortical excitability in a polarity specific manner and has been shown to influence learning and memory. tDCS may have both on-line and after-effects on learning and memory, and the latter are thought to be based upon tDCS-induced alterations in neurochemistry and synaptic function. We used ultra-high-field (7Â T) magnetic resonance spectroscopy (MRS), together with a robotic force adaptation and de-adaptation task, to investigate whether tDCS-induced alterations in GABA and Glutamate within motor cortex predict motor learning and memory. Note that adaptation to a robot-induced force field has long been considered to be a form of model-based learning that is closely associated with the computation and 'supervised' learning of internal 'forward' models within the cerebellum. Importantly, previous studies have shown that on-line tDCS to the cerebellum, but not to motor cortex, enhances model-based motor learning. Here we demonstrate that anodal tDCS delivered to the hand area of the left primary motor cortex induces a significant reduction in GABA concentration. This effect was specific to GABA, localised to the left motor cortex, and was polarity specific insofar as it was not observed following either cathodal or sham stimulation. Importantly, we show that the magnitude of tDCS-induced alterations in GABA concentration within motor cortex predicts individual differences in both motor learning and motor memory on the robotic force adaptation and de-adaptation task.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 99, 1 October 2014, Pages 237-243
Journal: NeuroImage - Volume 99, 1 October 2014, Pages 237-243
نویسندگان
Soyoung Kim, Mary C. Stephenson, Peter G. Morris, Stephen R. Jackson,