کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6027545 | 1580912 | 2014 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Manifold population modeling as a neuro-imaging biomarker: Application to ADNI and ADNI-GO
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
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چکیده انگلیسی
We propose a framework for feature extraction from learned low-dimensional subspaces that represent inter-subject variability. The manifold subspace is built from data-driven regions of interest (ROI). The regions are learned via sparse regression using the mini-mental state examination (MMSE) score as an independent variable which correlates better with the actual disease stage than a discrete class label. The sparse regression is used to perform variable selection along with a re-sampling scheme to reduce sampling bias. We then use the learned manifold coordinates to perform visualization and classification of the subjects. Results of the proposed approach are shown using the ADNI and ADNI-GO datasets. Three types of classification techniques, including a new MRI Disease-State-Score (MRI-DSS) classifier, are tested in conjunction with two learning strategies. In the first case Alzheimer's Disease (AD) and progressive mild cognitive impairment (pMCI) subjects were grouped together, while cognitive normal (CN) and stable mild cognitive impaired (sMCI) subjects were also grouped together. In the second approach, the classifiers are learned using the original class labels (with no grouping). We show results that are comparable to other state-of-the-art methods. A classification rate of 71%, of arguably the most clinically relevant subjects, sMCI and pMCI, is shown. Additionally, we present classification accuracies between CN and early MCI (eMCI) subjects, from the ADNI-GO dataset, of 65%. To our knowledge this is the first time classification accuracies for eMCI patients have been reported.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 94, 1 July 2014, Pages 275-286
Journal: NeuroImage - Volume 94, 1 July 2014, Pages 275-286
نویسندگان
R. Guerrero, R. Wolz, A.W. Rao, D. Rueckert, The Alzheimer's Disease Neuroimaging Initiative (ADNI) The Alzheimer's Disease Neuroimaging Initiative (ADNI),