Toward a brain functional connectivity mapping modality by simultaneous imaging of coherent brainwaves

- We propose a new brain functional connectivity visualization technique.
- Micro-Tesla SQUID MRI enables to image periodic brainwave oscillations.
- Brainwave magnetic resonance visualizes spatial conjecture of a coherent brainwave.
- We demonstrate the distinctive localization of closely-placed correlated brainwaves.
- Adiabatic step-up trick of the magnetic field enables brainwave magnetic resonance.

Matching the proton-magnetic-resonance frequency to the frequency of a periodic neural oscillation (e.g., alpha or gamma band waves) by magnetic resonance imaging techniques, enables direct visualization of brain functional connectivity. Functional connectivity has been studied by analyzing the correlation between coherent neural oscillations in different areas of the brain. In electro- or magneto-encephalography, coherent source reconstruction in a source-space is very tricky due to power leaking from the correlation among the sources. For this reason, most studies have been limited to sensor-space analyses, which give doubtful results because of volume current mixing. The direct visualization of coherent brain oscillations can circumvent this problem. The feasibility of this idea was demonstrated by conducting phantom experiments with a SQUID-based, micro-Tesla NMR/MRI system. We introduce an experimental trick, an effective step-up of the measurement B-field in a pulse sequence, to decouple the magnetic resonance signal from the strong magneto-encephalographic signal at the same frequency.