کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6027650 | 1580914 | 2014 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Beta oscillations reflect changes in motor cortex inhibition in healthy ageing
ترجمه فارسی عنوان
نوسانات بتا منعکس کننده تغییر در مهار قشر مغزی در سالمندان سالم است
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
چکیده انگلیسی
Beta oscillations are involved in movement and have previously been linked to levels of the inhibitory neurotransmitter GABA. We examined changes in beta oscillations during rest and movement in primary motor cortex (M1). Amplitude and frequency of beta power at rest and movement-related beta desynchronization (MRBD) were measured during a simple unimanual grip task and their relationship with age was explored in a group of healthy participants. We were able to show that at rest, increasing age was associated with greater baseline beta power in M1 contralateral to the active hand, with a similar (non-significant) trend in ipsilateral M1. During movement, increasing age was associated with increased MRBD amplitude in ipsilateral M1 and reduced frequency (in contralateral and ipsilateral M1). These findings would be consistent with greater GABAergic inhibitory activity within motor cortices of older subjects. These oscillatory parameters have the potential to reveal changes in the excitatory-inhibitory balance in M1 which in turn may be a useful marker of plasticity in the brain, both in healthy ageing and disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 91, 1 May 2014, Pages 360-365
Journal: NeuroImage - Volume 91, 1 May 2014, Pages 360-365
نویسندگان
Holly E. Rossiter, Emma M. Davis, Ella V. Clark, Marie-Hélène Boudrias, Nick S. Ward,