کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6027726 | 1580919 | 2014 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Distance informed Track-Weighted Imaging (diTWI): A framework for sensitising streamline information to neuropathology
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کلمات کلیدی
APMDCEADCROIFDOPATWITDIAUC - AUCdMRI - DMRIDiffusion-weighted MRI - MRI توزیع شدهFLAIR - اشتباهfluid attenuated inversion recovery - بهبود مورفین مایع کاهش می یابدTractography - تراکتوگرافی track density imaging - تراکم تصویر برداریPET imaging - تصویربرداری PETDiffusion imaging - تصویربرداری دیجیتالPositron emission tomography - توموگرافی گسیل پوزیترونWorld Health Organisation - سازمان بهداشت جهانیapparent diffusion coefficient - ضریب انتشار آشکارdist - محدودهArea under the concentration curve - محدوده تحت منحنی تمرکزregion-of-interest - منطقه مورد نظرfractional anisotropy - ناپیوستگی کسریInfiltration - نفوذHARDI - هاردیPET - پتcontrast enhanced - کنتراست افزایش یافته استdynamic contrast enhanced - کنتراست پویا افزایش یافته استWHO - کهGlioma - گلیوما
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
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چکیده انگلیسی
Track-Weighted Imaging (TWI), where voxel intensity is based on image metrics encoded along streamline trajectories, provides a mechanism to study white matter disease. However, with generalised streamline weighting, it is difficult to localise the precise anatomical source and spread of injury or neuropathology. This limitation can be overcome by modulating the voxel weight based on the distance of the voxel from a given anatomical location along the tract, which we term diTWI: distance informed Track-Weighted Imaging. The location of known neuropathology can be delineated on any given imaging modality (e.g. MRI or PET). To demonstrate the clinical utility of this approach, we measured tumour cell infiltration along WM fibre tracts in 13 patients with newly diagnosed glioblastoma and 1 patient with Anaplastic Astrocytoma. TWI and diTWI maps were generated using information obtained from dynamic contrast enhanced MRI (area under the curve, AUC) and diffusivity maps (ADC and FA) with tumour boundaries automatically extracted using a logistic regression classifier. The accuracy of the derived tumour volumes was compared to those generated using 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine (FDOPA) PET imaging. The accuracy of the tumour volumes generated from the diTWI maps was superior to volumes derived from the TWI, geometric distance or baseline AUC, FA and ADC maps. The relative overlap and relative dissimilarity rates for the diTWI generated tumour volumes after classification were found to be 82.3 ± 15.3% (range 69.1-91.9) and 16.9 ± 8.8% (range 7.9-37.5), respectively. These findings show that diTWI maps provide a useful framework for localising neuropathological processes occurring along WM pathways.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 86, 1 February 2014, Pages 60-66
Journal: NeuroImage - Volume 86, 1 February 2014, Pages 60-66
نویسندگان
Christopher Bell, Kerstin Pannek, Michael Fay, Paul Thomas, Pierrick Bourgeat, Olivier Salvado, Yaniv Gal, Alan Coulthard, Stuart Crozier, Stephen Rose,