A new method for structural volume analysis of longitudinal brain MRI data and its application in studying the growth trajectories of anatomical brain structures in childhood

Using the improved method to analyze longitudinal data, we study the growth trajectories of anatomical brain structures in childhood using the NIH pediatric MRI database. We report age- and gender-related growth trajectories of specific regions of the brain during childhood that could be used as a reference in studying the impact of neurological disorders on brain development.