Pre-clinical characterization of [11C]R05013853 as a novel radiotracer for imaging of the glycine transporter type 1 by positron emission tomography

► [11C]RO5013853 is a novel PET tracer for future human studies of the GlyT1. ► [11C]RO5013853 is specifically retained in brain regions known to express GlyT1. ► [11C]RO5013853 was used to determine the receptor occupancy of bitopertin (RG1678).