Physiological and modeling evidence for focal transcranial electrical brain stimulation in humans: A basis for high-definition tDCS

► Experimental transcranial electrical stimulation validates MRI-derived model of brain current delivery. ► High-Definition tDCS focally delivers current to motor cortex. ► Both TES and tDCS produce inward (normal) currents beneath the anode. ► The High-Definition electrode montage could be used for focal therapeutic tDCS.