Inter-individual differences in empathy are reflected in human brain structure

► We studied how individual variability in empathy is linked to brain structure. ► Affective empathy was linked to changes in the precuneus and anterior cingulate. ► Changes in the inferior frontal gyrus were also linked with affective empathy. ► Perspective taking was related to changes in the anterior cingulate. ► Personal distress was linked to changes in the somatosensory cortex and insula.