Neuropeptide S receptor gene: Fear-specific modulations of prefrontal activation

► NPSR1 modulates dorsolateral and medial prefrontal brain activation ► Lower frontal brain activity in NPSR1 risk allele carriers to fear-relevant stimuli ► Emotional but not cognitive regulation is affected by NPSR1 genotype ► Results suggest that NPSR1 A/A genotype offers protection against elevated anxiety