A quantitative spatial comparison of high-density diffuse optical tomography and fMRI cortical mapping

► Image-quality of high-density diffuse optical tomography is evaluated against fMRI. ► Functional maps of the visual cortex are used as a benchmark. ► We co-register subject-specific light models for DOT to MRI space. ► Center-of-mass and phase measures are used as quantitative metrics. ► The average localization error of HD-DOT is less than a typical gyral ridge size.