Imaging brain amyloid deposition using grating-based differential phase contrast tomography

► Study of amyloid deposition in a relevant model of Alzheimer's disease pathology. ► Method provides high contrast in brain, high resolution and a large field of view. ► Visualization of amyloid-plaque distribution in the whole brain was demonstrated. ► Automated segmentation and evaluation of Aβ-plaques at 4 stages of the disease. ► Validation of a new powerful method for ex vivo analysis of amyloid burden in mice.