Manganese enhanced MRI in rat hippocampus: A correlative study with synchrotron X-ray microprobe

► Good correlation between T1w-signal and Mn concentrations determined by SR-XRF ► Massive uptake of Mn in astrocytes along the hippocampal fissure ► Mn distribution in dentate gyrus and CA3 follows Zn distribution along mossy fibers ► Mn has negative impact on total Zn and Fe which could contribute to Mn neurotoxicity