A computational neurodegenerative disease progression score: Method and results with the Alzheimer's disease neuroimaging initiative cohort

► A computational neurodegenerative disease progression score (DPS) is proposed ► The DPS combines measurements from multiple biomarkers ► Validation with the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort ► An Alzheimer's DPS (ADPS) is computed for each subject and time-point in ADNI ► Evidence for a common Alzheimer's disease progression within ADNI subjects