Variants in the DYX2 locus are associated with altered brain activation in reading-related brain regions in subjects with reading disability

► Functional imaging data are an informative endophenotype for reading disability. ► A functional variant in DCDC2 associated with brain activation during reading tasks ► We nominally replicated association of TTRAP with imaging endophenotypes ► Future studies should examine cognitive, imaging, and genetic data in studying language deficits.