Imaging acute ischemic tissue acidosis with pH-sensitive endogenous amide proton transfer (APT) MRI-Correction of tissue relaxation and concomitant RF irradiation effects toward mapping quantitative cerebral tissue pH

► Amide proton transfer MRI is sensitive to pH. ► Quantitative tissue pH map can be estimated from in vivo APT MRI. ► pH MRI permits multi-parametric analysis of heterogeneous ischemic tissue damage.