The effect of handedness on the shape of the central sulcus

► The hand knob position can shift along the central sulcus according to individuals. ► Manifold learning can quantify the shape of the central sulcus. ► The left hand knob is sited more dorsally in dextrals than in sinistrals. ► Unlike sulcus size, the location of the hand knob is unchanged by forced dextrality. ► Cortical morphology holds a record of both innate biases and early experience.