Postprandial plasma PYY concentrations are associated with increased regional gray matter volume and rCBF declines in caudate nuclei - A combined MRI and H215O PET study

► Associations of physiologically released PYY with brain morphology and rCBF. ► Postprandial PYY is positively associated with caudate nuclei gray matter volume. ► Postprandial PYY is negatively associated with caudate nuclei rCBF. ► Caudate nuclei activity modulates prefrontal and limbic/paralimbic activity.