Modulation of CNS pain circuitry by intravenous and sublingual doses of buprenorphine

► Dose response measurement of evoked pain BOLD signal for 0.1 and 0.2 mg/70 kg IV BUP. ► Comparison of evoked pain BOLD responses due to 0.2 mg/70 kg IV and 2.0 mg SL BUP. ► Characterization of dose response using functional connectivity for 2 IV BUP doses. ► Characterization of functional connectivity along PK curve for 2.0 mg SL BUP.