Abnormal subcortical deep-gray matter susceptibility-weighted imaging filtered phase measurements in patients with multiple sclerosis

► We investigate iron content on SWI in 233 MS patients and 126 controls. ► Increased iron content is detected in MS patients compared to controls. ► Increased iron content is related to lesion burden and brain atrophy in MS. ► SWI is a powerful tool for evaluating the degree of iron deposition in MS.