The effects of APOE on the functional architecture of the resting brain

► Investigated the effects of APOE on functional connectivity using resting-state fMRI. ► Found differences between APOE genotype groups in several resting-state networks. ► Overall, ε4 and ε2 carriers showed similar changes relative to ε3 homozygotes. ► Results point to intrinsic, not AD-related, effect of APOE on functional networks. ► Role of APOE in neurodevelopment may relate to effects on brain function.