Construction of a consistent high-definition spatio-temporal atlas of the developing brain using adaptive kernel regression

► A new approach for constructing high-definition 4D atlases is presented. ► Multi-modal MR images from 204 preterm neonates (age-range 26-44 weeks PMA) are used. ► The resulting atlas retains a consistent level of detail at every time-point. ► The atlas has greater anatomic definition than currently available 4D atlases. ► Such a sharp atlas enables improved registration between the atlas and individuals.