Neuroanatomy in adolescents and young adults with 22q11 Deletion Syndrome: Comparison to an IQ-matched group

► 22q11DS can be independently associated with learning disability or schizophrenia. ► Hippocampal and cerebellar volumes differ between 22q11DS and higher IQ controls. ► Regional cortical morphology is abnormal in 22q11DS but not in matched IQ controls. ► The corpus callosum is enlarged in 22q11DS but not in matched IQ controls. ► Atypical cortical and callosal maturation may contribute to psychosis risk in 22q11DS.