Functioning of neural systems supporting emotion regulation in anxiety-prone individuals

►Following training in cognitive reappraisal (an effective emotion regulation skill), anxious and control subjects were equally adept at decreasing subjective negative emotions. ►However, anxious subjects required greater engagement of lateral and medial PFC in order to successfully reduce negative emotions. ►Regions of increased activation in anxious subjects included left dorsolateral PFC, bilateral ventrolateral PFC, dorsomedial PFC and subgenual ACC.