کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6034206 | 1188753 | 2010 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Imaging genetics of mood disorders
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کلمات کلیدی
Amygdala - آمیگدال، بادامهFunctional connectivity - اتصال عملکردی Major depressive disorder - اختلال افسردگی عمدهmood disorders - اختلال خلقیorbitofrontal cortex - قشر اوربیتوفرنتالanterior cingulate cortex - قشر سینگولیت قدامی، کورتکس سینگولیت قدامیEmotion - هیجانHippocampus - هیپوکامپ Genetics - ژنتیکImaging genetics - ژنتیک تصویربرداریventromedial prefrontal cortex - کورتکس prefrontal ventromedial
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
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چکیده انگلیسی
Mood disorders are highly heritable and have been linked to brain regions of emotion processing. Over the past few years, an enormous amount of imaging genetics studies has demonstrated the impact of risk genes on brain regions and systems of emotion processing in vivo in healthy subjects as well as in mood disorder patients. While sufficient evidence already exists for several monaminergic genes as well as for a few non-monoaminergic genes, such as brain-derived neurotrophic factor (BDNF) in healthy subjects, many others only have been investigated in single studies so far. Apart from these studies, the present review also covers imaging genetics studies applying more complex genetic disease models of mood disorders, such as epistasis and gene-environment interactions, and their impact on brain systems of emotion processing. This review attempts to provide a comprehensive overview of the rapidly growing field of imaging genetics studies in mood disorder research.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 53, Issue 3, 15 November 2010, Pages 810-821
Journal: NeuroImage - Volume 53, Issue 3, 15 November 2010, Pages 810-821
نویسندگان
Christian Scharinger, Ulrich Rabl, Harald H. Sitte, Lukas Pezawas,