Impaired error-likelihood prediction in medial prefrontal cortex in schizophrenia

►fMRI study of medial prefrontal cortex (MPFC) dysfunction in schizophrenia. ►Abnormal error-likelihood predictions in MPFC in schizophrenia. ►Abnormal error-unexpectedness evaluations in MPFC in schizophrenia. ►Dysfunctional prediction mechanism leads to abnormal predictions and evaluations. ►MPFC dysfunction in schizophrenia involves impaired outcome predictions.