Segmentation priors from local image properties: Without using bias field correction, location-based templates, or registration

► Voxel signatures-multiscale textures-can generate tissue-class probability priors. ► Prior generation does not require volume registration or bias field estimation. ► Signature-based priors obviate need for population-based tissue probability maps. ► Signature-based priors outperform location-based priors in segmentation. ► Approach readily extensible for brains with significant deviations from the normal.