DISC1 is associated with cortical thickness and neural efficiency

► We examine effects of variation in DISC1 on cortical thickness and neural efficiency. ► Phe allele carriers of the DISC1 SNP Leu607Phe have reduced cortical thickness. ► Neural activity during working memory task was increased in Phe allele carriers. ► Working memory performance did not differ within Leu607Phe genotype groups. ► The Phe allele is associated with neural inefficiency during a working memory task.