Covariance modeling of MRI brain volumes in memory circuitry in schizophrenia: Sex differences are critical

► Significant sex differences in connectivity of verbal memory in schizophrenia. ► Females are more accurate in verbal memory and in schizophrenia effect is larger. ► Covariance of parietal and prefrontal cortices different by sex in schizophrenia. ► Sex differences in correlation between memory accuracy and brain regions. ► Sex-specific disruption of key verbal memory brain regions in schizophrenia.