The role of GABAergic modulation in motor function related neuronal network activity

► Pharmaco-MEG can determine pharmacological mechanisms of functional oscillations. ► MRBD and PMBR are both directly dependent upon the spontaneous beta activity. ► MRBD in primary motor cortex is enhanced by increased GABA-A receptor drive. ► PMBR and MRGS in primary motor cortex are non-GABA-A receptor mediated.