کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6036243 1188774 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chronic stress is linked to 5-HT1A receptor changes and functional disintegration of the limbic networks
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
Chronic stress is linked to 5-HT1A receptor changes and functional disintegration of the limbic networks
چکیده انگلیسی

There are increasing reports about stress related cognitive and psychic declines in subjects who have no psychiatric premorbidity, depression, or major life trauma. Yet, little is known about the underlying neurobiology. Based on the typical symptomatology, fMRI data suggesting that stress activates the limbic circuits, and animal data showing a major involvement of the 5-HT1A receptor in stress regulation, we hypothesized that enduring daily stress causes widespread limbic dysfunctions, and specific changes of the 5-HT1A receptor.To test these hypotheses combined PET studies were carried out in 16 chronically stressed, and 16 non-stressed subjects. Limbic function was tested by measuring cerebral blood flow during rest, and when using an odor activation paradigm. 5-HT1A receptor binding potential (BP) was assessed with [11C]WAY100635. All subjects went through a battery of neuropsychological tests.Stressed subjects showed a functional disconnection between the amygdala and ACC/medial prefrontal cortex (mPFC), and an impaired odor activation of the ACC. They also displayed a reduced 5-HT1A receptor BP in the anterior cingulate (ACC), the insular-cortex, and the hippocampus. Their performance in attention-, odor discrimination-, and semantic memory tasks was impaired, and correlated with the BP-values in the respective region. The degree of reported stress was inversely correlated with activation of ACC, and the 5-HT1A receptor BP in the amygdala and hippocampus.Enduring every day psychosocial stress seems to be associated with a limbic reduction of 5-HT1A receptor binding and functional disintegration of ACC/mPFC. These changes support the notion of an impaired top-down regulation of stress stimuli, and identify potential targets for early treatment.

Research Highlights► Chronic psychosocial stress is associated with disintegration of limbic networks. ► Stress patients display functional disconnection between amygdala and ACC/mPFC. ► Patients show limbic reductions of the 5-HT1A receptor binding. ► The degree of reported stress inversely correlates with ACC activation. ► The detected changes suggest a long-standing limbic malfunction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 55, Issue 3, 1 April 2011, Pages 1178-1188
نویسندگان
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