Is 2Â +Â 2Â =Â 4? Meta-analyses of brain areas needed for numbers and calculations

►Normative adult neurofunctional model of mental arithmetic. ►Mathematical performance emerges from a large set of brain areas. ►Cingulate gyrus, insula and cerebellum play a role in mathematical cognition. ►Prefrontal cortices contribute differentially based on task demands. ►Laterality was modulated by arithmetic operations in parietal and prefrontal areas.