کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6038111 | 1188793 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modulation of striatal dopamine D1 binding by cognitive processing
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
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چکیده انگلیسی
There is strong evidence that dopamine (DA) is implicated in higher-order cognitive functioning, but it remains controversial whether D1 receptor binding can be modified by cognitive activity. We examined striatal D1 binding potential (BP) in 20 younger (22-30Â years) and 20 older (65-75Â years) persons who underwent two [11C] SCH 23390 PET measurements, one while resting and one while performing a cognitive task taxing inhibitory functioning. The younger persons showed significant task-related BP reductions in sensorimotor, limbic, and associative striatum during cognitive activity compared to rest. Older persons showed no reliable BP reductions in any striatal subregion. These findings demonstrate that D1 receptor binding can be modified by cognitive activity in younger persons, but also provide novel evidence for the notion that human aging is associated not only with lower DA receptor density but also with altered modifiability of the DA system.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 48, Issue 2, 1 November 2009, Pages 398-404
Journal: NeuroImage - Volume 48, Issue 2, 1 November 2009, Pages 398-404
نویسندگان
Sari Karlsson, Lars Nyberg, Per Karlsson, HÃ¥kan Fischer, Petra Thilers, Stuart MacDonald, Yvonne Brehmer, Anna Rieckmann, Christer Halldin, Lars Farde, Lars Bäckman,