کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6039290 | 1188816 | 2009 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Domain-specific reorganization of semantic processing after extensive damage to the left temporal lobe
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
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![عکس صفحه اول مقاله: Domain-specific reorganization of semantic processing after extensive damage to the left temporal lobe Domain-specific reorganization of semantic processing after extensive damage to the left temporal lobe](/preview/png/6039290.png)
چکیده انگلیسی
We investigated with fMRI the cortical correlates of recovery of semantic processing in a patient (DL) with left temporal damage. Names of animals, plant, and artifacts (semantic conditions) and reversed words (baseline condition) were auditorily presented to the patient and nine control subjects in a category monitoring task. Data analyses showed large differences between the patterns of domain-specific semantic activation observed in DL and the control subjects, which could be attributed to a cortical reorganization compensating for the damaged part of the semantic processing system in DL. Such reorganization relied on three main mechanisms, first, upholding of a subset of the structurally intact domain-specific regions, second, functional changes (both decreases and increases) of the domain specificity in several structurally intact regions that are normally engaged in the domain-specific network and, third, recruitment of supplementary domain-specific areas. Thus, in DL, animal-specific processing engaged supplementary areas in the left lingual gyrus and right cuneus, which correspond to animal-specific regions usually engaged in more demanding semantic tasks whereas the supplementary areas recruited for artifact-specific processing within the left superior/middle occipital lobe and right angular gyrus probably are endowed with a related but not domain-specific, semantic function. In contrast, no supplementary area contributed to plant-specific processing in DL. These findings suggest that the pattern of cortical reorganization consecutive to damage to the semantic processing network depends on the particular domain-specific function sustained by the damaged areas and the capacity of the remaining areas to assume this function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 45, Issue 2, 1 April 2009, Pages 572-586
Journal: NeuroImage - Volume 45, Issue 2, 1 April 2009, Pages 572-586
نویسندگان
Bénédicte Léonard, Marie-Pierre de Partz, Cécile Grandin, Agnesa Pillon,