کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6039379 1188819 2008 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nonlinear dynamic causal models for fMRI
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
Nonlinear dynamic causal models for fMRI
چکیده انگلیسی
This paper presents a nonlinear extension of DCM that models such processes (to second order) at the neuronal population level. In this way, the modulation of network interactions can be assigned to an explicit neuronal population. We present simulations and empirical results that demonstrate the validity and usefulness of this model. Analyses of synthetic data showed that nonlinear and bilinear mechanisms can be distinguished by our extended DCM. When applying the model to empirical fMRI data from a blocked attention to motion paradigm, we found that attention-induced increases in V5 responses could be best explained as a gating of the V1 → V5 connection by activity in posterior parietal cortex. Furthermore, we analysed fMRI data from an event-related binocular rivalry paradigm and found that interactions amongst percept-selective visual areas were modulated by activity in the middle frontal gyrus. In both practical examples, Bayesian model selection favoured the nonlinear models over corresponding bilinear ones.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 42, Issue 2, 15 August 2008, Pages 649-662
نویسندگان
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