کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6039459 | 1188819 | 2008 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chronic vagus nerve stimulation for treatment-resistant depression decreases resting ventromedial prefrontal glucose metabolism
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کلمات کلیدی
Ventromedial prefrontal cortex (vmPFC)subgenual anterior cingulateAmygdala - آمیگدال، بادامهTreatment-resistant depression - افسردگی مقاوم به درمانFunctional magnetic resonance imaging (fMRI) - افامآرآی، تصویرسازی تشدید مغناطیسی کارکردی Electroconvulsive therapy (ECT) - الکترو کانواسی درمان (ECT)Deep brain stimulation (DBS) - تحریک مغزی عمیق (DBS)computed tomography - توموگرافی کامپیوتری یا سی تی اسکن یا مقطعنگاری رایانهایdefault-mode - حالت پیش فرضPleasure - لذتGlucose metabolism - متابولیسم گلوکزNeuromodulation - نورومدولاسیون Nucleus accumbens - هسته accumbensEmotion - هیجان
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Vagus nerve stimulation (VNS) is used as an adjunctive therapy for treatment-resistant depression (TRD). Its mechanism of action is not fully understood. Longitudinal measurement of changes in brain metabolism associated with VNS can provide insights into this new treatment modality. Eight severely depressed outpatients who were highly treatment-resistant underwent electrical stimulation of the left vagus nerve for approximately one year. The main outcome measures were resting regional brain glucose uptake measured with positron emission tomography (PET) and the 24-item Hamilton Depression Scale. The most significant and extensive change over one year of chronic VNS localized to the ventromedial prefrontal cortex extending from the subgenual cingulate to the frontal pole. This region continued to decline in metabolism even toward the end of the study. Clinically, this cohort showed a trend for improvement. No correlations surfaced between change in glucose uptake and depression scores. However, the sample size was small; none remitted; and the range of depression scores was limited. Chronic VNS as adjunctive therapy in patients with severe TRD produces protracted and robust declines in resting brain activity within the ventromedial prefrontal cortex, a network with dense connectivity to the amygdala and structures monitoring the internal milieu.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 42, Issue 2, 15 August 2008, Pages 879-889
Journal: NeuroImage - Volume 42, Issue 2, 15 August 2008, Pages 879-889
نویسندگان
José V. Pardo, Sohail A. Sheikh, Graeme C. Schwindt, Joel T. Lee, Michael A. Kuskowski, Christa Surerus, Scott M. Lewis, Faruk S. Abuzzahab, David E. Adson, Barry R. Rittberg,