کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6040274 | 1188844 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Myelination shapes functional activity in the developing brain
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In humans, the function of spatial integration (SI) develops slowly, continuing through childhood into adolescence. To reveal its neural substrate in children and to examine the role of myelination in shaping SI-dependent functional activity, we applied a combined fMRI/MTI technique capable of tracking functional (BOLD response) and morphological (myelination) signs of maturation. Fourteen children (age 7-13) were scanned while viewing bilateral gratings, which either obeyed Gestalt grouping rules or violated them. A contrast between these stimuli revealed the BOLD response presumably induced by interhemispheric SI. It was limited to a small ventral stream territory in the lingual gyrus that corresponds to the VP part of the SI-induced activation found in adults in VP/V4 areas. The BOLD response correlated with myelination of splenial fibers. The data suggest that the activation of the extrastriate areas that enable an SI function depends on the maturation of long-range cortico-cortical connections.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 38, Issue 3, 15 November 2007, Pages 511-518
Journal: NeuroImage - Volume 38, Issue 3, 15 November 2007, Pages 511-518
نویسندگان
Eleonora Fornari, Maria G. Knyazeva, Reto Meuli, Philippe Maeder,