Interrelationships among physical activity, depression, homocysteine, and metabolic syndrome with special considerations by sex

► Relationships between physical activity and co-morbidities were examined. ► Physical activity was inversely related to depression and homocysteine. ► Active individuals were also less likely to have metabolic syndrome. ► Active individuals were less likely to simultaneously have all three morbidities. ► Greater strengths of associations occurred for women compared to men.