کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6089939 1208562 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Applied nutritional investigationPlasma klotho levels decrease in both anorexia nervosa and obesity
ترجمه فارسی عنوان
تحقیقات تغذیه ای کاربردی سطح کلوتو پلاسما در هر دو حالت بی اشتهایی و چاقی کاهش می یابد
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی

ObjectiveThe aim of this study was to examine the associations of klotho with body mass index (BMI) in patients with restricting-type anorexia nervosa (r-AN) and obesity.MethodWe examined plasma klotho as well as adiponectin and its isoform levels in comparison in 11 obese patients, 12 r-AN patients, and 11 control participants.ResultsPlasma klotho levels were markedly lower in the obesity and r-AN groups than in the control group. Moreover, plasma klotho levels increased significantly after the recovery of BMI in r-AN patients. Total and high-molecular-weight adiponectin levels were significantly decreased only in obesity. There was no relationship between klotho and total adiponectin levels or klotho and respective adiponectin isoform levels in the entire study population.ConclusionsThese results suggest that klotho may reflect normal nutritional state, and that the decrease of klotho in r-AN and obesity may underlie the deteriorating processes of these disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition - Volume 29, Issue 9, September 2013, Pages 1106-1109
نویسندگان
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