Temozolomide Increases the Number of Mismatch Repair-Deficient Intestinal Crypts and Accelerates Tumorigenesis in a Mouse Model of Lynch Syndrome

We developed a mouse model of Lynch syndrome (Lgr5-CreERT2;Msh2flox/− mice) and found that environmental factors can modify the number and mutability of the MMR-deficient stem cells. These findings provide evidence that environmental factors can promote development of neoplasias and tumors in patients with Lynch syndrome.