Keywords: CSC; cancer stem cells; EMT; epithelial to mesenchymal transition; MET; mesenchymal to epithelial transition; AML; acute myeloid leukemia; ALDH1; aldehyde dehydrogenase 1; BCSC; breast cancer stem cell; Lgr5; G-protein-coupled receptor 5; GSC; glioblastom
مقالات ISI (ترجمه نشده)
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Keywords: 5-Aza; 5-Aza-2-deoxycytidine; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; BIR; baculoviral inhibitor of apoptosis repeat; CAD; caspase-activated deoxyribonuclease; CDK; cyclin-dependent kinase; cIAP; cellular inhibitor of apoptosis; CL
Keywords: Anti-PD1 receptor; BRAF 600E mutation; Melanoma; Pembrolizumab; Primary solitary cerebral malignant melanoma; Primary solitary intracranial malignant melanoma; CT; Computed tomography; GTR; Gross total removal; IQR; Interquartile range; MMM; Metastatic ma
Keywords: Glioblastoma; Meta-analysis; Recurrence; Repeat surgery; Systematic review; CI; Confidence interval; EC; Effect coefficient; GBM; Glioblastoma; HR; Hazard ratio; OS; Overall survival; QoL; Quality of life; TMZ; Temozolomide;
Keywords: AMPK; AMP-activated protein kinase; DCA; Dichloroacetate; FACD; Fatty acyl CoA dehydrogenase; G-6-Pase; Glucose-6-phosphatase; HFD; High-fat diet; HGP; Hepatic glucose production; KCT; β-ketoacyl CoA thiolase; LDH; Lactate dehydrogenase; MPC; Mitochondri
Keywords: Brain neoplasm; Clinical trials; Glioblastoma; Immunotherapeutic; Immunotherapy; Vaccine; APC; Antigen-presenting cell; APVAC; Actively personalized vaccination; BBB; Blood-brain barrier; CMV; Cytomegalovirus; CNS; Central nervous system; CSF; Cerebrosp
Keywords: Anticancer activity; Apoptosis; DNA repair; Glioblastoma; Seaweed compounds; Temozolomide; AIC; 5-aminoimidazole-4-carboxamide; Akt; Protein kinase B (PKB); AP site; apurinic/apyrimidinic site; AP-1; activator protein-1; APE-1; AP endonuclease; Bax; Bcl-2
Keywords: ACSVL3; acyl-coA synthetase VL3; ALDH1; aldehyde dehydrogenase; ALDOA; aldolase A; ALDOC; aldolase C; AMPK; 5â² AMP-activated protein kinase; ASNS; asparagine synthetase; BTICs; brain tumor initiating cells; 3-BrOP; 3-bromo-2-oxopropionate-1-propyl ester
Keywords: AML; acute myeloid leukemia; APL; acute promyelocytic leukemia; ADAM; a disintegrin and metalloproteinase enzymes; ALDH; aldehyde dehydrogenase; ABC; ATP - binding cassette; BWS; Beckwith-Wiedemann syndrome; BMP; bone morphogenetic proteins; CSC; cancer s
Keywords: GBM; glioblastoma multiforme; TMZ; temozolomide; MGMT; O6 methylguanine- DNA methyltransferase; HDAC; histone deacetylase; HDACI; HDAC inhibitor; HMG-CoA; 3-hydroxy-3-methylglutaryl-CoA; VPA; valproic acid; ROS; reactive oxygen species; NaB; sodium butyra
Keywords: EORTC; European Organisation for Research and Treatment of Cancer; FDA; Food and Drug Administration; GBM; glioblastoma multiforme; GFR; growth factor receptor; IDH; isocitrate dehydrogenase gene; KPS; Karnofsky Performance Status; MGMT; O6-methylguanine-
Keywords: Recurrent malignant glioma; ATRX; Alpha thalassemia/mental retardation syndrome X-linked; Bev; Bevacizumab; CNS; Central nervous system; EGFR; Epidermal growth factor receptor; GBM; Glioblastoma multiforme; Gy; Gray; HRQoL; Health-related quality of life;
Keywords: Chemotherapy; Health-related quality of life; High-grade glioma; KPS; Recurrence therapy; Recurrent surgery; Re-radiation; Bev; Bevacizumab; CCNU; Lomustine; EORTC QLQ-BN20; European Organisation for Research and Treatment of Cancer Quality of Life Questi
Keywords: Biomarkers; Checkpoint molecules; Cytokines; Glioblastoma; Immunotherapy; Microbiome; Mutational landscape; CB; Cintredekin besudotox; CNS; Central nervous system; CTLA-4; Cytotoxic T lymphocyte antigen 4; CyTOF; Cytometry by time-of-flight; EGFR; Epiderm
Keywords: GBM; glioblastoma; TMZ; temozolomide; CPD; Cumulative Population Doubling; RTCT; Relative Time to Cross a Threshold; rAUC; relative Area Under Curve; RPR; Relative Proliferation Rate; RendCPD; Relative end CPD; Temozolomide; Glioblastoma; Cumulative popul
Keywords: ACPP; activated cell-penetrating peptide; AFM; atomic force microscopy; AN; angiopeptin; ANP; NP modified with ACPP peptide; APE-1; apurinic endonuclease-1; AU; gold; AUC; area under the curve; AUNP; gold nanoparticles; AUNS; gold nanoshells; BAT; brain a
Keywords: Glioblastoma; Treatment; Review; Pharmacology; Targeted therapy; Stem cell; AKT; protein kinase B; BBB; blood-brain barrier; BCNU; carmustin; CCNU; lomustin; c-MET; hepatocyte growth factor receptor; EGF(R); epidermal growth factor (receptor); EGFRvIII; e
Keywords: AAV; adeno-associated virus; BBB; blood-brain barrier; BBBD; blood-brain barrier disruption; BCNU; bis-chloroethylnitrosourea or carmustine; BNCT; boron neutron capture therapy; BPN; brain-penetrating nanoparticle; CNS; central nervous system; DOX; do
Keywords: GART, glycinamide ribonucleotide formyl transferase; TMZ, temozolomide; PCNA, proliferating cell nuclear antigen; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; MCTS, multicellular tumor spheroidGART; Glioma; TMZ; Proliferation
Keywords: 5-ALA; 5-amino-levulinic acid; RGD; arginine-glycine-aspartic acid; BBB; blood-brain barrier; BCNU; carmustine; CASANT; carmustine sustained-release implant; CNS; central nervous system; CED; convection-enhanced delivery; c(RGDyK); cyclic arginineâ
Keywords: ÎKG; α-ketoglutarate; AML; acute myeloid leukemia; BCAT1; branched-chain amino acid transporter 1; BRD4; bromodomain-containing protein 4; D-2HG; D-2-hydroxyglutarate or R-2-hydroxyglutarate; D-2HGA; D-2-hydroxyglutarate aciduria; D2HGDH; D-2-hydroxyglu
Keywords: AML; acute myeloid leukemia; CAM-DR; cell adhesion-mediated drug resistance; CCP; charge-conversion polymer; CLL; chronic lymphocytic leukemia; CNS; central nervous system; CSC; cancer stem cell; EGFR; epidermal growth factor receptor; EPR; enhanced perme
Keywords: siRNA; small interfering RNA; AON; antisense oligonucleotides; shRNA; small hairpin RNA; pDNA; plasmid DNA; CYP3A; cytochrome P450 3A; MDR; multidrug resistance; MDR1; multidrug resistance protein 1; Pgp; P-glycoprotein; TRAIL; tumor necrosis factor-relat
Determinants for Effective ALECSAT Immunotherapy Treatment on Autologous Patient-Derived Glioblastoma Stem Cells
Keywords: ALECSAT; Autologous Lymphoid Effector Cells Specific Against Tumor Cells; CTA; Cancer/testis antigens; CSC; Cancer stem cells; CTL; Cytotoxic T lymphocytes; FBS; Fetal bovine serum; GBM; Glioblastoma; HGG; High-grade glioma; MHC; Major histocompatibility
Development of temozolomide coated nano zinc oxide for reversing the resistance of malignant glioma stem cells
Keywords: G. glabra; TMZ; ZnO NPs; Human glioblastoma cells; Plausible mechanism;
Value of 18F-FET PET in adult brainstem glioma
Keywords: ADC; apparent diffusion coefficient; BSG; brain stem glioma; Cho; choline; CT; computed tomography; DTI; diffusion tensor imaging; DWI; diffusion weighted imaging; FET; 18F-fluoro-ethyl-tyrosine; FLAIR; fluid-attenuated inversion recovery; GBM; glioblasto
X-inactive-specific transcript: A long noncoding RNA with complex roles in human cancers
Keywords: AR; androgen receptor; ATG7; autophagy related 7; Bcl2; B-cell lymphoma-2; BRCA1; breast cancer-associated protein 1; CCND1; cyclin D1; CDK4/6; cyclin dependent kinase 4/6; CDX1; caudal type homeobox 1; CRC; colorectal cancer; EMT; epithelial mesenchymal
Imaging biomarkers guided anti-angiogenic therapy for malignant gliomas
Keywords: 18F-FDOPA; 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine; 18F-FLT; [18F]-fluoro-3-deoxy-3-L-fluorothymidine; ADC; apparent diffusion coefficient; AVOL; arterio-venous overlap; BBB; blood brain barrier; CBF; cerebral blood flow; CBV; cerebral blood volume;
S-phase Specific Downregulation of Human O6-Methylguanine DNA Methyltransferase (MGMT) and its Serendipitous Interactions with PCNA and p21cip1 Proteins in Glioma Cells
Keywords: MGMT; O6-methylguanine DNA methyltransferase; PCNA; proliferating nuclear antigen; His Tag; Hexahistidine tag; DAPI; 4,6-Diamidino-2-phenylindole; rMGMT; recombinant MGMT protein; tet; tetracycline; IB; immunoblot; WB; western blot; LV; lenti-viral transf
Xanthone-rich extract from Gentiana dinarica transformed roots and its active component norswertianin induce autophagy and ROS-dependent differentiation of human glioblastoma cell line
Keywords: Gentiana dinarica transformed roots; Xanthone; Norswertianin; Glioblastoma; Cell differentiation; Autophagy; GBM; Glioblastoma multiforme; Atg; autophagy-related proteins; mTOR; mammalian target of rapamycin; PI3K; phosphoinositide 3-kinase; AMPK; AMP-act
Drug-induced xenogenization of tumors: A possible role in the immune control of malignant cell growth in the brain?
Keywords: Cyclophosphamide (PubChem CID: 2907); DTIC (Dacarbazine) (PubChem CID: 5353562); GPI 15427 (PubChem CID: 11739525); Lomeguatrib (PubChem CID: 3025944); NU 1025 (PubChem CID: 63306); Temozolomide (PubChem CID: 5394); BER; base excision repair; CD2F1; hybri
Stereotactic Brachytherapy with Iodine-125 Seeds Plus Temozolomide Induced Complete and Durable Remission in a Patient with Recurrent Primary Central Nervous System Lymphoma
Keywords: Iodine-125 seeds; Primary central nervous system lymphoma; Recurrent stereotactic brachytherapy; Temozolomide; 125-I; Iodine-125; DLBCL; Diffuse large B-cell lymphoma; HD-MTX; High-dose methotrexate; MGMT; O6-Methylguanine-DNA methyl-transferase; MRI; Mag
Combination with TMZ and miR-505 inhibits the development of glioblastoma by regulating the WNT7B/Wnt/β-catenin signaling pathway
Keywords: miRNA; microRNA; TMZ; temozolomide; GBM; glioblastoma; CCK-8; Cell Counting Kit-8; NBT; non-cancerous brain tissues; TMZ; miR-505; WNT7B; Wnt/β-catenin; Glioblastoma;
Tacrine derivatives stimulate human glioma SF295 cell death and alter important proteins related to disease development: An old drug for new targets
Keywords: TMZ; temozolomide; GBM; glioblastoma multiforme; CNS; central nervous system; ROS; reactive oxygen species; BBB; blood-brain barrier; CC50; 50% cytotoxic concentration; TEM; transmission electron microscopy; SI; selectivity index; âÏm; mitochondrial me
Double-barreled gun: Combination of PARP inhibitor with conventional chemotherapy
Keywords: PARP; poly (ADP-ribose) polymerase; TMZ; temozolomide; BER; base-excision repair; MGMT; O-6-methylguanine-DNA methyltransferase; NHEJ; non-homologous end joining; HR; homologous recombination; 3-AB; 3-aminobenzamide; MTIC; 5-(3-methyltriazen-1-yl)imidazol
Modulating autophagy in cancer therapy: Advancements and challenges for cancer cell death sensitization
Keywords: 3-MA; 3-Methyl Adenine; Akt; Protein kinase B; AMP; Adenosine monophosphate; AMPK; AMP-activated protein kinase; Atg; Autophagy related genes; ATP; Adenosine triphosphate; Bak; Bcl-2 homologous antagonist/killer; Bax; Bcl-2-associated X protein; BCL-2; B-
Synthesis of PET probe O6-[(3-[11C]methyl)benzyl]guanine by Pd0-mediated rapid C-[11C]methylation toward imaging DNA repair protein O6-methylguanine-DNA methyltransferase in glioblastoma
Keywords: MGMT; O6-methylguanine-DNA methyltransferase; TMZ; temozolomide; O6-BG; O6-benzylguanine; PET; positron emission tomography; AGT; O6-alkylguanine-DNA alkyltransferase; TFA; trifluoroacetyl; [11C]mMeBG; 11C-labeled O6-[(3-methyl)benzyl]guanine; BOC; tert-b
The use of TMZ embedded hydrogels for the treatment of orthotopic human glioma xenografts
Keywords: Hydrogel; TMZ; Glioma;
Knockdown of linc-OIP5 inhibits proliferation and migration of glioma cells through down-regulation of YAP-NOTCH signaling pathway
Keywords: CCK8; Cell Counting Kit-8; CNS; central nervous system; DMEM; Dulbecco's modified Eagle's medium; GBM; glioblastoma; Hes-1; hairy and enhancer of split-1; Jag-1; Jagged-1; LincRNAs; long intergenic noncoding RNAs; LncRNAs; Long noncoding RNAs; MALAT1; Met
Original ArticlemiR-181d/MALT1 regulatory axis attenuates mesenchymal phenotype through NF-κB pathways in glioblastoma
Keywords: Glioma; Non-coding RNA; Mesenchymal transition; Transcriptome subtype; NF-κB signaling; GBM; glioblastoma; MES; mesenchymal subtype; PN; proneural subtype; TMZ; temozolomide; NC; negative control; FACS; fluorescence-activated cell sorting; GO; Gene Ontol
State of the art: pediatric brain stem gliomas
Keywords: Brain stem gliomas; Children; Biopsy; MRI; Therapy; Gliomas del tronco cerebral; Niños; Biopsia; Resonancia magnética; Terapia; DIPG; diffuse intrinsic pontine glioma; RT; radiotherapy; VP shunt; ventriculoperitoneal shunt; TMZ; temozolomide; PFS; progr
Original ArticleHDAC4 and HDAC6 sustain DNA double strand break repair and stem-like phenotype by promoting radioresistance in glioblastoma cells
Keywords: HDAC4; HDAC6; Glioblastoma; Radiotherapy; Radioresistance; GBM; glioblastoma; TMZ; temozolomide; RT; radiotherapy; HDACs; Histone deacetylases; HATs; Histone acetyltransferases; DSBs; DNA double-strand breaks; OS; Overall survival; shRNA; short hairpin RN
Metabolic reprogramming in cancer cells, consequences on pH and tumour progression: Integrated therapeutic perspectives with dietary lipids as adjuvant to anticancer treatment
Keywords: α-SMA; α-smooth muscle actin; AMPK; AMP-activated protein kinase; bHLH; basic Helix-Loop-Helix; DHA; docosahexaenoic acid (22:6n-3); Drp1; dynamin-related protein 1; ECM; extracellular matrix; EMT; epithelial-to-mesenchymal transition; EPA; eicosapentae
FTY720 inhibits the Nrf2/ARE pathway in human glioblastoma cell lines and sensitizes glioblastoma cells to temozolomide
Keywords: FTY720; Glioblastoma; Nrf2; TMZ; Combination chemotherapy;
Original ArticlePatterns of Recurrence After Resection of Malignant Gliomas With BCNU Wafer Implants: Retrospective Review in a Single Institution
Keywords: BCNU wafers; Glioma; Pattern; Recurrence; AA; Anaplastic astrocytoma; AO; Anaplastic oligodendroglioma; AOA; Anaplastic oligoastrocytoma; GBM; Glioblastoma multiforme; Gd; Gadolinium; TMZ; Temozolomide; 5ALA; 5-aminolevulinic avid;
Formation of multicellular tumor spheroids induced by cyclic RGD-peptides and use for anticancer drug testing in vitro
Keywords: Cyclo-RGDfK (PubChem CID: 10196873); Doxorobicin (PubChem CID: 443939); Curcumin (PubChem CID: 969516); Temozolomide (PubChem CID: 5394); 2D; two-dimensional; 3D; three-dimensional; MTS; multicellular tumor spheroids; RGD; arginine-glycine-aspartic acid;
Guidelines, “minimal requirements” and standard of care in glioblastoma around the Mediterranean Area: A report from the AROME (Association of Radiotherapy and Oncology of the Mediterranean arEa) Neuro-Oncology working party
Keywords: OS; overall survival; PFS; progression-free survival; WHO; World Health Organization; MA; Mediterranean area; AROME; association of radiotherapy and oncology of the Mediterranean area; MTDs; multidisciplinary teams meetings; MRI; magnetic resonance imagin
Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapy
Keywords: MNK; MAP kinase-interacting kinase; TMZ; temozolomide; GBM; glioblastoma; MTC; medullary thyroid carcinoma; ERK; extracellular signal-regulated kinases; eIF4E/G1; eukaryotic translation initiation factor 4E/G1; MAPK; mitogen-activated protein kinase; GAPD
5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells
Keywords: Glioblastoma; Apoptosis resistance; Multidrug resistance; Translation inhibition; Lycorine; Haemanthamine; ATCC; American Type Culture Collection; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM; Dulbecco's modified Eagle's medium; DMF; dimethylformamide; DMS
A novel temozolomide analog, NEO212, with enhanced activity against MGMT-positive melanoma in vitro and in vivo
Keywords: CFA; colony formation assay; MGMT; O6-methylguanine-DNA methyltransferase; O6-BG; O6-benzylguanine; POH; perillyl alcohol; TMZ; temozolomide; NEO212; perillyl alcohol covalently linked to temozolomide (TMZ-POH); O6-methylguanine-DNA methyltransferase; MGM