کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6095838 1209836 2010 26 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical-Alimentary TractMeta-analysis Shows That Detection of Circulating Tumor Cells Indicates Poor Prognosis in Patients With Colorectal Cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Clinical-Alimentary TractMeta-analysis Shows That Detection of Circulating Tumor Cells Indicates Poor Prognosis in Patients With Colorectal Cancer
چکیده انگلیسی

Background & AimsThe prognostic significance of circulating (CTCs) and disseminated tumor cells in patients with colorectal cancer (CRC) is controversial. We performed a meta-analysis of available studies to assess whether the detection of tumor cells in the blood and bone marrow (BM) of patients diagnosed with primary CRC can be used as a prognostic factor.MethodsWe searched the Medline, Biosis, Science Citation Index, and Embase databases and reference lists of relevant articles (including review articles) for studies that assessed the prognostic relevance of tumor cell detection in the peripheral blood (PB), mesenteric/portal blood (MPB), or BM of patients with CRC. Meta-analyses were performed using a random effects model, with hazard ratio (HR) and 95% confidence intervals (95% CIs) as effect measures.ResultsA total of 36 studies, including 3094 patients, were eligible for final analyses. Pooled analyses that combined all sampling sites (PB, MPB, and BM) associated the detection of tumor cells with poor recurrence-free survival (RFS) (HR = 3.24 [95% CI: 2.06-5.10], n = 26, I2 = 77%) and overall survival (OS) (2.28 [1.55-3.38], n = 21, I2 = 66%). Stratification by sampling site showed that detection of tumor cells in the PB compartment was a statistically significant prognostic factor (RFS: 3.06 [1.74-5.38], n = 19, I2 = 78%; OS: 2.70 [1.74-4.20], n = 16, I2 = 59%) but not in the MPB (RFS: 4.12 [1.01-16.83], n = 8, I2 = 75%; OS: 4.80 [0.81-28.32], n = 5, I2 = 82%) or in the BM (RFS: 2.17 [0.94-5.03], n = 4, I2 = 78%; OS: 1.50 [0.52-4.32], n = 3, I2 = 84%).ConclusionDetection of CTCs in the PB indicates poor prognosis in patients with primary CRC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 138, Issue 5, May 2010, Pages 1714-1726.e13
نویسندگان
, , , , , , , , , ,