کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6103974 1211134 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research ArticleIndustrial, not fruit fructose intake is associated with the severity of liver fibrosis in genotype 1 chronic hepatitis C patients
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Research ArticleIndustrial, not fruit fructose intake is associated with the severity of liver fibrosis in genotype 1 chronic hepatitis C patients
چکیده انگلیسی

Background & AimsUnhealthy food intake, specifically fructose, has been associated with metabolic alterations and with the severity of liver fibrosis in patients with non-alcoholic fatty liver disease. In a cohort of patients with genotype 1 chronic hepatitis C (G1 CHC), we tested the association of fructose intake with the severity of liver histology.MethodsAnthropometric and metabolic factors, including waist circumference (WC), waist-to-hip ratio (WHR), dorso-cervical lipohypertrophy and HOMA were assessed in 147 consecutive biopsy-proven G1 CHC patients. Food intake, namely industrial and fruit fructose, was investigated by a three-day structured interview and a computed database.All biopsies were scored by an experienced pathologist for staging and grading (Scheuer classification), and graded for steatosis, which was considered moderate-severe if ⩾20%. Features of non-alcoholic steatohepatitis (NASH) in CHC were also assessed (Bedossa classification).ResultsMean daily intake of total, industrial and fruit fructose was 18.0 ± 8.7 g, 6.0 ± 4.7 g, and 11.9 ± 7.2 g, respectively. Intake of industrial, not fruit fructose, was independently associated with higher WHR (p = 0.02) and hypercaloric diet (p <0.001). CHC patients with severe liver fibrosis (⩾F3) reported a significantly higher intake of total (20.8 ± 10.2 vs. 17.2 ± 8.1 g/day; p = 0.04) and industrial fructose (7.8 ± 6.0 vs. 5.5 ± 4.2; p = 0.01), not fruit fructose (12.9 ± 8.0 vs. 11.6 ± 7.0; p = 0.34). Multivariate logistic regression analysis showed that older age (OR 1.048, 95% CI 1.004-1.094, p = 0.03), severe necroinflammatory activity (OR 3.325, 95% CI 1.347-8.209, p = 0.009), moderate-severe steatosis (OR 2.421, 95% CI 1.017-6.415, p = 0.04), and industrial fructose intake (OR 1.147, 95% CI 1.047-1.257, p = 0.003) were independently linked to severe fibrosis. No association was found between fructose intake and liver necroinflammatory activity, steatosis, and the features of NASH.ConclusionsThe daily intake of industrial, not fruit fructose is a risk factor for metabolic alterations and the severity of liver fibrosis in patients with G1 CHC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hepatology - Volume 59, Issue 6, December 2013, Pages 1169-1176
نویسندگان
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