کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6115880 1215933 2014 22 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Utility of inflammatory markers in predicting the aetiology of pneumonia in children
ترجمه فارسی عنوان
سودمندی نشانگرهای التهابی در پیشگیری از علل پنومونی در کودکان
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی
We aimed to investigate the diagnostic value of applying cut-off levels of inflammatory markers and to develop a prediction model for differentiation between bacterial and viral infections in paediatric community-acquired pneumonia based on C-reactive protein (CRP), neutrophil, and white cell counts (WCC). Amongst 401 children, those with bacterial pneumonia were older than those with viral pneumonia (P < 0.001). Compared to viral, bacterial infections had a higher median CRP level (P < 0.001), whereas WCC and neutrophil count were not different. Bacterial infections were associated with higher CRP >80 mg/L than viral infections (P = 0.001), but levels <20 mg/L were not discriminatory (P = 0.254). Receiver operating characteristic curve of the model for differentiating bacterial from viral pneumonia based on age, CRP, and neutrophil count produced area under the curve of 0.894 with 75.7% sensitivity and 89.4% specificity. This aetiological discriminant prediction model is a potentially useful tool in clinical management and epidemiological studies of paediatric pneumonia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diagnostic Microbiology and Infectious Disease - Volume 79, Issue 4, August 2014, Pages 458-462
نویسندگان
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